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Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic . Indication : For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc dosage: Adult- PO/IM/IV- The recommended dose range is 0.5 to 3gm every 6 hours. Child- 25 to 50mg/kg/day. Mechanism of action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins- it is possible that Ampicillin interferes with an autolysin inhibitor.

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